scientific publications

Genetic variants and the risk of renal impairment in decompensated cirrhosis: a multi-ancestry genome-wide association study

Lukas Otero Sanchez, Joan Clària, Clélia Galvanin, Ferran Aguilar, Richard Layese, Matteo Serra, Laura Jiménez-Gracia, Paula Nieto, Darko Castven, Sona Frankova, Milan Jirsa, David Tornai, Anna Curto-Vilalta, Alberto Queiroz Farias, Maria Papp, Patricia Momoyo Zitelli, Paolo Caraceni, Giacomo Zaccherini, Luciana L Goncalves, Carlo Alessandria, Gustavo Pereira, Wim Laleman, Adrian C Gadano, Salvatore Piano, Angelo Z Mattos, Desislava Germanova, Valério Lucidi, Daphnée Soret, Line Carolle Ntandja Wandji, Frank Erhard Uschner, Aldo Torre, Victor Vargas, Liliana S C Mendes, Rajeshwar P Mookerjee, Carlos Benitez, Mario R Alvares-da-Silva, Myriam Remmelink, Paulo L Bittencourt, Agustin Albillos, Claudia Alves Couto, Rafael Bañares, Manuel Mendizabal, Delphine Degré, Claudio L Toledo, Martin Janicko, Daniel F Mazo,Mauricio Castillo Barradas, William Bernal, Adelina Zarela Lozano Miranda, P Martín Padilla-Machaca, Alexander Zipprich, René Malé-Velázquez,Christophe Moreno, André Castro Lyra, Flair Carrilho, Javier Fernandez, Jonel Trebicka, Rajiv Jalan, Paolo Angeli, CANONIC, PREDICT, ACLARA,ANRS CO12 CirVir, and CIRRAL study groups, Horia Stefanescu, Pierre-Emmanuel Rautou, Stephan Buch, Alexandre Louvet, Jens U Marquardt,Thierry Gustot, Holger Heyn, Juan C Nieto, Vicente Arroyo, Nathalie Ganne-Carrié, Jan Sperl, Richard Moreau, Philippe Mathurin, Pierre Nahon, Eric Trépo

The Lancet Gastroenterology & Hepatology, Published online September 18, 2026

Detection of esophageal varices and prediction of hepatic decompensation in unresectable hepatocellular carcinoma using AI

Asier Rabasco Meneghetti, Claudia Campani, Charles Roux, Zunamys I. Carrero, Dan-Adrian Popica, Giuliana Amaddeo, Marie Lequoy, Clémence Hollande, Sarah Mouri, Mathilde Wagner, Vincent Plaforet, Sabrina Sidali, Maxime Ronot, Marika Rudler, Alain Luciani, Olivier Sutter, Eleonore Spitzer, Hélène Regnault, Sanaâ El Mouhadi , Violaine Ozenne , Nathalie Ganne-Carrié , Mohamed Bouattour , Jean Charles Nault, Dominique Thabut , Jakob Nikolas Kather , Manon Allaire 

Journal of Hepatology, June 2026, Pages: 1149-1163 Volume 84, Issue 6

Artificial intelligence in liver cancer — new tools for research and patient management

Julien Calderaro, Laura Žigutytė, Daniel Truhn, Ariel Jaffe & Jakob Nikolas Kather

Nature Reviews Gastroenterology & Hepatology volume 21, pages585–599 (2024)

Use of artificial intelligence for liver diseases: A survey from the EASL congress 2024

Laura Žigutytė, Thomas Sorz-Nechay, Jan Clusmann, Jakob Nikolas Kather

JHEP Reports, December 2024. vol. 6 j 101209

From whole-slide image to biomarker prediction: end-to-end weakly supervised deep learning in computational pathology

Nature Protocols volume 20, pages293–316 (2025) 

Machine Learning Predicts Hepatocellular Carcinoma Risk from Routine Clinical Data: A Large Population-Based Multicentric Study

Jan Clusmann ;Paul-Henry Koop ;David Y. Zhang;Felix van Haag ;Omar S.M. El Nahhas ;Tobias Seibel ;Laura Žigutytė ;Apichat Kaewdech ;Julien Calderaro ;Frank Tacke ;Tom Luedde ;Daniel Truhn ;Tony Bruns ;Kai Markus Schneider ;Jakob Nikolas Kather ;Carolin V. Schneider

Cancer Discovery (2026) 16 (7): 1304–1322.

Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis

Eric Trépo, Jessica Zucman-Rossi & Jean-Charles Nault

Nature Reviews Gastroenterology & Hepatology  Published: 12 February 2026

High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen-Specific Tregs

K Fischer, O Horno, B Raposo, I Godinho, H Ribeiro, H Veiga-Fernandes, M Martínez-López

Journal of Immunology research, 28 November 2025

Focus on Semaglutide 2.4 mg/week for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis

Salvatore Petta, KyeongJin Kim, Giovanni Targher, Stefano Romeo, Silvia Sookoian, Ming-Hua Zheng , Alessio Aghemo, Luca Valenti

Liver International, 2025 November; volume 45 issue 11

Bringing genetic testing into the clinical management of people with MASLD: Are we there yet?

Luca Valenti, Hannes Hagström 

Journal of hepatology / Volume 83, Issue 4 p825-827October 2025

Neuro‐ILC Interactions in Host Physiology and Defence

Cristina Godinho-Silva, Miguel Rendas, Henrique Veiga-Fernandes

European Journal of Immunology, Volume 55, issue 8, August 2025

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics

Stefano Romeo, Luca Valenti

Liver International, volume 45 issue 9, September 2025

Differences between hepatocellular carcinoma caused by alcohol and other aetiologie

Nathalie Ganne-Carrié, Pierre Nahon

Journal of Hepatology, May 2025. vol. 82 j 909–917 917

Associations between fruit and vegetable consumption and HCC occurrence in patients with cirrhosis

Florian Manneville , Zineb Zouakia , Séverine Donneger , Leopold K Fezeu , Alice Bellicha , Pierre Nahon , Mathilde Touvier , Nathalie Ganne-Carrié , Chantal Julia

JHEP Rep. 2025 Feb 13;7(5):101355.

Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis

Marko Šestan, Bruno Raposo, Miguel Rendas, David Brea, Roksana Pirzgalska, Ana Rasteiro,  Maria Aliseychik, Inês Godinho, Hélder Ribeiro, Tania Carvalho, Stephan Wueest, Daniel Konrad, and Henrique Veiga-Fernandes 

Science,17 Jan 2025, Vol 387, Issue 6731

Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism

Rosellina M. Mancina, Luca Valenti & Stefano Romeo

Nature Metabolism volume 7, pages2199–2211 (2025)

Neuroepithelial VIP–VIPR1 interactions differentially control enteric type 1 and type 2 immunity

Roksana M. Pirzgalska, Beatriz Henriques-Alves, Bruno Raposo, Eric de Sousa, Júlio Torres, Jaechan Ryu, Cristina Godinho-Silva, Miguel Rendas, Madalena Pereira, Inês Godinho, Hélder Ribeiro, Vasco Correia, Manuel O. Jakob, Patrycja M. Forster, Christoph Wilhelm, Christoph S. N. Klose, Ricardo Rio-Tinto, Verena M. Link, Tânia Carvalho, Carlos M. Minutti, Manuela Ferreira & Henrique Veiga-Fernandes

Nature Immunology volume 26, pages2244–2255 (2025)

Prevalence and Determinants of Liver Disease in Relatives of Italian Patients with Advanced MASLD

Serena Pelusi, Luisa Ronzoni, Jessica Rondena,∙ Chiara Rosso,∙ Grazia Pennisi,∙  Paola Dongiovanni, Sara Margarita, Rossana Carpani, Giorgio Soardo, Daniele Prati,  Annalisa Cespiati, Salvatore Petta, Elisabetta Bugianesi, Luca Valenti

Clinical Gastroenterology and Hepatology, vol 22, November 2024